Thursday, March 21, 2013

'Sideline quasars' helped to stifle early galaxy formation

Mar. 21, 2013 ? University of Colorado Boulder astronomers targeting one of the brightest quasars glowing in the universe some 11 billion years ago say "sideline quasars" likely teamed up with it to heat abundant helium gas billions of years ago, preventing small galaxy formation.

CU-Boulder Professor Michael Shull and Research Associate David Syphers used the Hubble Space Telescope to look at the quasar -- the brilliant core of an active galaxy that acted as a "lighthouse" for the observations -- to better understand the conditions of the early universe. The scientists studied gaseous material between the telescope and the quasar with a $70 million ultraviolet spectrograph on Hubble designed by a team from CU-Boulder's Center for Astrophysics and Space Astronomy.

During a time known as the "helium reionization era" some 11 billion years ago, blasts of ionizing radiation from black holes believed to be seated in the cores of quasars stripped electrons from primeval helium atoms, said Shull. The initial ionization that charged up the helium gas in the universe is thought to have occurred sometime shortly after the Big Bang.

"We think 'sideline quasars' located out of the telescope's view reionized intergalactic helium gas from different directions, preventing it from gravitationally collapsing and forming new generations of stars," he said. Shull likened the early universe to a hunk of Swiss cheese, where quasars cleared out zones of neutral helium gas in the intergalactic medium that were then "pierced" by UV observations from the space telescope.

The results of the new study also indicate the helium reionization era of the universe appears to have occurred later than thought, said Shull, a professor in CU-Boulder's astrophysical and planetary sciences department. "We initially thought the helium reionization era took place about 12 billion years ago," said Shull. "But now we think it more likely occurred in the 11 to 10 billion-year range, which was a surprise."

A paper on the subject by Shull and Syphers was published online this week in the Astrophysical Journal.

The Cosmic Origins Spectrograph used for the quasar observations aboard Hubble was designed to probe the evolution of galaxies, stars and intergalactic matter. The COS team is led by CU Professor James Green of CASA and was installed on Hubble by astronauts during its final servicing mission in 2009. COS was built in an industrial partnership between CU and Ball Aerospace & Technologies Corp. of Boulder.

"While there are likely hundreds of millions of quasars in the universe, there are only a handful you can use for a study like this," said Shull. Quasars are nuclei in the center of active galaxies that have "gone haywire" because of supermassive black holes that gorged themselves in the cores, he said. "For our purposes, they are just a really bright background light that allows us to see to the edge of the universe, like a headlight shining through fog."

The universe is thought to have begun with the Big Bang that triggered a fireball of searing plasma that expanded and then become cool neutral gas at about 380,000 years, bringing on the "dark ages" when there was no light from stars or galaxies, said Shull. The dark ages were followed by a period of hydrogen reionization, then the formation of the first galaxies beginning about 13.5 billion years ago. The first galaxies era was followed by the rise of quasars some 2 billion years later, which led to the helium reionization era, he said.

The radiation from the huge quasars heated the gas to 20,000 to 40,000 degrees Fahrenheit in intergalactic realms of the early universe, said Shull. "It is important to understand that if the helium gas is heated during the epoch of galaxy formation, it makes it harder for proto-galaxies to hang on to the bulk of their gas. In a sense, it's like intergalactic global warming."

The team is using COS to probe the "fossil record" of gases in the universe, including a structure known as the "cosmic web" believed to be made of long, narrow filaments of galaxies and intergalactic gas separated by enormous voids. Scientists theorize that a single cosmic web filament may stretch for hundreds of millions of light years, an eye-popping number considering that a single light-year is about 5.9 trillion miles.

COS breaks light into its individual components -- similar to the way raindrops break sunlight into the colors of the rainbow -- and reveals information about the temperature, density, velocity, distance and chemical composition of galaxies, stars and gas clouds.

For the study, Shull and Syphers used 4.5 hours of data from Hubble observations of the quasar, which has a catalog name of HS1700+6416. While some astronomers define quasars as feeding black holes, "We don't know if these objects feed once, or feed several times," Shull said. They are thought to survive only a few million years or perhaps a few hundred million years, a brief blink in time compared to the age of the universe, he said.

"Our own Milky Way has a dormant black hole in its center," said Shull. "Who knows? Maybe our Milky Way used to be a quasar."

The first quasar, short for "quasi-stellar radio source," was discovered 50 years ago this month by Caltech astronomer Maarten Schmidt. The quasar he observed, 3C-273, is located roughly 2 billion years from Earth and is 40 times more luminous than an entire galaxy of 100 billion stars. That quasar is receding from Earth at 15 percent of the speed of light, with related winds blowing millions of miles per hour, said Shull.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ZOGqnnnX0-U/130321111020.htm

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Wednesday, March 20, 2013

Researchers identify a promising target for multiple sclerosis treatments

Wednesday, March 20, 2013

A team of basic and clinical scientists led by the University of Montreal Hospital* Research Centre's (CRCHUM) Dr. Nathalie Arbour has opened the door to significantly improved treatments for the symptoms of Multiple Sclerosis (MS). In a study selected as among the top 10% most interesting articles published in the Journal of Immunology, the team identifies the elevated presence in MS patients of a type of white blood cell (CD4 T cell) that expresses NKG2C, a highly-toxic molecule harmful to brain tissues.

In close collaboration with clinicians at the University of Montreal Hospital and the Montreal Neurological Institute, McGill University, Dr. Arbour's team studied tissues from healthy subjects and MS patients. This approach enabled the team to uncover a novel mechanism by which CD4 T cells expressing NKG2C can directly target brain cells having a specific corresponding ligand found only in MS patients. "These results are very encouraging," says Arbour, "since they provide us with a much more refined picture of how the brain cells of MS patients are targeted by the immune system and provide us with a clearer understanding of how to go about blocking their action."

There is no known cure for this auto-immune disease of the central nervous system. While there are a number of approved MS therapies targeting molecules expressed by immune cells, they are sometimes too broad in their application. They can suppress the efficiency of the immune system but also open the way for serious infections in some MS patients such as progressive multifocal leukoencephalopathy, a serious viral disease that can cause death in people with severe immune deficiency, such as MS patients on immunosuppressive medication.

"Our research has made an important step in getting around this problem. Because NKG2C is specifically expressed by a subset of CD4 T cells only found in MS patients, targeting this receptor would not affect large populations of immune cells, but only those which produce the symptoms characteristic of this debilitating disease," explains Arbour.

For patients this discovery could translate into improved treatments aimed at decreasing the progression of the disease and its symptoms, without the risk of potentially lethal infections and therefore improving their quality of life.

###

University of Montreal Hospital Research Centre (CRCHUM):

Thanks to University of Montreal Hospital Research Centre (CRCHUM) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127368/Researchers_identify_a_promising_target_for_multiple_sclerosis_treatments

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Leeds owner says seeks investors, not buyer

By Martin de Sa'Pinto and Keith Weir

ZURICH/LONDON (Reuters) - The Dubai-based owner of Leeds United said it is seeking new investors in the English football club but denied it plans to sell up completely three months after buying the team.

A statement from owner GFH Capital issued by the Championship (second division) club on Wednesday tried to reassure fans that the owners remained committed to Leeds after buying out majority shareholder Ken Bates only in December.

(http://www.leedsunited.com/news/20130320/a-message-from-the-owners_2247585_3116320)

But the statement will not quell uncertainty about the future of the former English champions as it conflicts with comments made by its Bahrain-based parent Gulf Finance House.

Two sources close to the matter told Reuters earlier on Wednesday that parent GFH had all but completed a sale of the club, with just one or two legal issues left to resolve.

The new consortium seeking to buy Leeds is led by Steve Parkin, a locally-based businessman who made his money in road haulage. Parkin attempted to buy the club in 2004, prior to it being snapped up by former Chelsea owner Bates.

The sources declined to be named either because they still conduct business with GFH or have links to the new buyers.

Sources said Parkin is working with potential partners from the Middle East on the deal. One source said Parkin had met potential partners when watching his racehorses in training at the famous Godolphin stables in Dubai.

Parkin declined to comment when contacted by Reuters on Wednesday.

NEW INVESTMENT

GFH Capital bought Leeds in December after protracted negotiations lasting more than six months and despite concerns over their financial firepower.

Rumours the new owners were planning a swift exit first surfaced last month.

They appeared to be confirmed when parent GFH reported in its 2012 financial report that talks on a sale of the stake had already begun. The sale plan was reported by Reuters on Tuesday evening.

"GFH Capital is looking for investment in part of its share in the club, not its entirety," the subsidiary said in response to the speculation.

In its annual report GFH has booked a $10.4 million (6.8 million pounds) profit on the deal, despite not having sold the club yet, attributing this to the "bargain price" it paid for Leeds.

The putative gain allowed GFH to post a profit and is the latest in a series of one-time items in recent financial reports that have allowed GFH to appear profitable despite bleeding cash.

NO "CRAZY MONEY"

The cashflow statement indicates GFH has so far paid over $33 million for Leeds, with a further $42.7 million in liabilities. The statement values the club, classed as "assets held for sale" on the balance sheet, at $88 million.

In the accounts, GFH Chairman Esam Yousif Janahi calls the club "a high yielding investment opportunity".

The sources said negotiations on behalf of GFH were being led by its CEO Hisham Alrayes.

GFH Capital acting CEO Salem Patel and deputy David Haigh were now only peripherally involved in the club despite fronting the takeover when it was announced at Elland Road in December, they added.

Leeds were English champions in 1992 and are one of the best-supported teams outside of the elite Premier League.

Patel said GFH Capital would not spend "crazy money" to reach the top flight. That dampened fans' hopes that the new owners would replicate the lavish funding that has transformed clubs like Chelsea and Manchester City over the past decade.

GFH Capital said it had injected 10 million pounds into Leeds to boost the squad and as working capital.

Leeds are currently in 10th place in the 24-team second-tier Championship and retain only faint hopes of reaching the play-offs for a place in the big money Premier League.

(Editing by Elaine Hardcastle)

Source: http://news.yahoo.com/gfh-capital-says-seeking-investment-leeds-not-full-160220575--finance.html

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Eric Schmidt Urges India to Stop Controlling the Web

Eric Schmidt has kicked off a mini Asia tour in India by calling on the government to stop pursuing control of the Internet and instead focus on how technology can help the population and local businesses.

Google has confirmed that Schmidt, who is scheduled to visit Myanmar in addition to other unnamed countries across the continent, is already in India as he prepares to speak at?The Guardian?s?Big Tent Activate India event?in New Delhi on March 21. In a byline posted to the Times of India, the Google Executive chairman appealed to the Indian government to change its focus and be positive about the Internet.

India has invested considerable energy trying to police the Web in the past eighteen months or so. A proposal to introduce real-time content monitoring?drew controversy in late 2011, while its legal system has housed a number of cases against Internet firms like Google, Facebook, Yahoo and Twitter. The companies stood accused of allowing unsuitable content to exist on India Web space.

Avoiding any direct mention of the cases and the conflict between maintaining Indian culture while allowing freedom of expression, Schmidt focuses his editorial on the choice between the open or closed Web:

Almost one billion of [the world's new Internet users in the next ten years] will come online in India. They will have different needs from people online today and expect different things from the internet. Now is the moment for India to decide what kind of internet it wants for them: an open internet that benefits all or a highly regulated one that inhibits innovation.

The past 10 years show that the safest economic, social and?political bet?is on openness. Where there is a free and open Web, where there is unbridled technological progress, where information can be disseminated and consumed freely, society flourishes.

He provides examples of of this benefit, citing specific Google programs in India ? the Google+ Hangout with the country?s finance minister, and?Women Entrepreneurs on the Web, a program being piloted in India ? and the benefits of long distance learning, video communication, and more.

Equally, Schmidt argues, the Internet can enable local businesses ? and startups in particular ? to flourish. The Web gives them a platform to take their businesses international, and explore vast potential that an offline world simply cannot offer provide:

The most striking Indian internet innovations won?t come from big institutions or companies moving online, however. They will come from Indians solving local problems. We know that India?s internet infrastructure allows Indian engineers to solve the problems of small businesses in other countries. If India plays its cards right, we?ll soon see Indian engineers and Indian small businesses tackling Indian problems first, then exporting the solutions that work best.

In a similar vein to his comments about the potential for greater access to technology in North Korea ? which is clearly a more extreme example than India ? Schmidt says that the Internet can only improve the situation and society in a country:

India could reap a huge dividend from the Internet?s growth ? the same one other countries have realized, or are about to. In all the places I?ve?traveled?to, I?ve yet to see a country whose situation worsened with the arrival of the internet.

That?s an important point since Indian courts and politicians have previously voiced their keenness?to?introduce a Chinese style censorship policy to keep negative influences away. Schmidt does acknowledge that not every aspect of the Internet is good, but his parting comment warns that???in seeking to control all of [the Internet, India authorities will] stop good Indians from doing great things?.

You can read the full byline here.

Related:?Eric Schmidt discusses Google?s competitors, China, acquisitions and more

Headline image via?Spencer Platt / Getty Images

Source: http://thenextweb.com/google/2013/03/19/googles-eric-schmidt-calls-on-india-to-stop-policing-the-web-and-focus-on-innovation/

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Tuesday, March 19, 2013

Hillary backs same-sex marriage (CNN)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/291845032?client_source=feed&format=rss

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Chrysler recalls Dodge Challengers for fire risk

Chrysler has issued an unusually dire warning to some owners of its Dodge Challenger muscle car warning them to park the vehicles until it can make repairs due to a risk of fire.

According to Chrysler, the wiring harness is the source of the problem due a batch of potentially mis-wired electrical components. If that?s the case, the harness can overheat and lead to a fire. The problem affects only those models equipped with a V-6 engine.

The maker says it so far received word of seven incidents involving the 2013 Dodge Challenger. It is warning motorists to park the vehicles outside of their garages and away from homes or other structures in case they do catch fire.

The Detroit Bureau: The 10 least (and most) expensive states for auto insurance

The recall involves 4,459 of the coupes built between December 3 and January 24 of this year. Chrysler reports 2,500 have been delivered to customers, the rest still on dealer lots. The problem does not affect owners of Challenger models equipped with the maker?s bigger V-8 engines.

While automakers often take their time reaching out to customers involved in recalls, Chrysler is attempting to contact owners immediately by phone or mail to alert them to the problem. It says it will offer free loaners to affected owners until repairs can be made.

The Detroit Bureau: Obama Wants to Use Oil, Gas Drilling Royalties for $2 bil Clean Car Research Trust

The urgent warning is unusual but not unique. Last July, Ford Motor Co. warned 11,500 owners of the then-new 2013 Escape crossover to park their cars because of a defective fuel line that could split and lead to a fire.

In 2010, meanwhile, U.S. Transportation Secretary Ray LaHood said he felt owners of some Toyota vehicles should park their vehicles due to a problem related to so-called unintended acceleration. The nation?s top automotive safety chief quickly reversed that recommendation, however.

The Detroit Bureau: Production Shortages Mean Higher Prices, Fewer Choices for Hyundai Buyers

Chrysler plans to make repairs to the Challenger as quickly as possible at no charge to affected owners.

The maker advises owners of 2013 Challengers equipped with V-6 engines to call their dealer to determine if their vehicles are covered by the recall.

Copyright ? 2009-2013, The Detroit Bureau

Source: http://www.nbcnews.com/business/chrysler-recalls-dodge-challengers-fire-risk-1C8911683

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Bloomberg cigarette plan gets praise, criticism

NEW YORK (AP) ? Anti-smoking advocates and health experts hailed proposals from Mayor Michael Bloomberg that would keep cigarettes out of sight in New York City stores, while tobacco companies and smokers called it an overreach.

The ban, which would be the first of its kind in the U.S., is aimed at discouraging young people from smoking.

Keeping cigarettes under wraps could help, anti-smoking advocates say, citing studies that link exposure to smoking with starting it. Shops from corner stores to supermarkets would have to keep tobacco products in cabinets, drawers, under the counter, behind a curtain or in other concealed spots. Officials also want to stop shops from taking cigarette coupons and honoring discounts, and are proposing a minimum price for cigarettes, though it's below what the going rate is in much of the city now.

While some of the research focuses on cigarette advertising, an English study of 11-to-15-year-olds published last month in the journal Tobacco Control found that simply noticing tobacco products on display every time a youth visited a shop raised the odds he or she would at least try smoking by threefold, compared to peers who never noticed the products.

"What's exciting about this (New York City proposal) is that this is the most comprehensive set of tobacco-control regulations that affect stores or the retail outlets," said Kurt Ribisl, a professor of public health and cancer prevention specialist at the University of North Carolina. Moreover, cigarettes' visibility can trigger impulse buys by smokers who are trying to quit, he and city officials say.

The American Cancer Society Cancer Action Network, the American Lung Association, other anti-smoking groups and several City Council members applauded Bloomberg's announcement, made at a Queens hospital on Monday. City Council Speaker Christine Quinn, who largely controls what goes to a vote, said through her office that she "supports the goal of these bills" but noted they would get a full review.

The ban on displaying cigarettes follows similar laws in Iceland, Canada, England and Ireland, but it would be the first such measure in the U.S. It's aimed at discouraging young people from smoking. According to the Rockland County Times, the Village of Haverstraw in Rockland County passed such a ban last April, but rescinded it four months later because it couldn't afford to fight a lawsuit brought by tobacco companies and convenience stores.

"Such displays suggest that smoking is a normal activity," Bloomberg said. "And they invite young people to experiment with tobacco."

But smokers and cigarette sellers said the measure was overreaching.

"I don't disagree that smoking itself is risky, but it's a legal product," said Audrey Silk, who's affiliated with a smokers-rights group that has sued the city over previous regulations. "Tobacco's been normal for centuries. ... It's what he's doing that's not normal."

Slated to be introduced to the City Council on Wednesday, the anti-smoking proposal was also a sign that a mayor who has built a reputation as a public health crusader isn't backing off after a high-profile setback last week, when a judge struck down the city's novel effort to ban supersized, sugary drinks. The city is appealing that decision.

"We're doing these health things to save lives," he said Monday.

Bloomberg, a billionaire who also has given $600 million of his own money to anti-smoking efforts around the world, began taking on tobacco use shortly after he became mayor in 2002. Adult smoking rates have since fallen by nearly a third ? from 21.5 percent in 2002 to 14.8 percent in 2011, Health Commissioner Dr. Thomas Farley said.

But the youth rate has remained flat, at 8.5 percent, since 2007. Some 28,000 city public high school students tried smoking for the first time in 2011, city officials say.

Measures in other countries have been coupled with bars on in-store advertising, but those nations have different legal standards around advertising and free speech. The New York proposal would still allow shops to display cigarette advertising and signs saying tobacco products were sold, raising the question of how effective it will be just to put the products under wraps.

But convenience store owners fear it could affect their business, by potentially leaving customers uncertain whether the shop carries their favorite brand and making them wait while a proprietor digs out a pack, said Jeff Lenard, a spokesman for the National Association of Convenience stores.

"It slows down the transaction, and our name is convenience stores," he said.

Jay Kim, who owns a Manhattan deli on 34th Street, saw the proposal as a bid to net fines.

"I know the city wants to collect money," he said at his store, where packs of cigarettes can be seen behind the counter, along with numerous signs warning of the dangers of smoking and prohibiting sales to minors.

Bloomberg, for his part, emphasized that collecting money was "not the reason."

The displays would be checked as part of the shops' normal city inspections; information on the potential penalties wasn't immediately available Monday night. Repeated violations of some of the other provisions, including the minimum-price and coupon ban, could get a store shuttered.

Stores that make more than half their revenue from tobacco products would be exempt from the display ban. Customers under 18, the legal age for buying cigarettes in New York, are barred from such stores without parents.

While the federal government regulates tobacco, states have some say in rules surrounding how it's sold.

Several of New York City's smoking regulations have survived court challenges. But a federal appeals court said last year that the city couldn't force tobacco retailers to display gruesome images of diseased lungs and decaying teeth. In that case, the court ruled that the federal government gets to decide how to warn people about the dangers of smoking.

The nation's largest tobacco company said the latest proposal also was too much.

"To the extent that this proposed law would ban the display of products to adult tobacco consumers, we believe it goes too far," said David Sutton, a spokesman for Richmond, Va.-based Altria Group Inc., parent company of Philip Morris USA, which makes the top-selling Marlboro brand. The company supported federal legislation that in 2009 gave the Food and Drug Administration the power to regulate tobacco products, which includes various retail restrictions, Sutton noted.

New York City smokers already face some of the highest cigarette prices in the country. With city and state taxes totaling $5.85 a pack, it's not uncommon for a pack to cost $13 or more in Manhattan. The proposed minimum price is $10.50, including taxes; city officials said it was aimed largely at clamping down on sales of smuggled and untaxed cigarettes.

Other public health measures Bloomberg has championed include pressuring restaurants to use less salt and add calorie counts to menus, and banning artificial trans fats from restaurant meals.

Jennifer Bailey, smoking as she waited for a bus on 34th Street, was no fan of the proposed tobacco restrictions or Bloomberg's other public health initiatives.

"It's like New York has become a ... dictatorship," she said.

___

Associated Press writers Deepti Hajela in New York and Michael Felberbaum in Richmond, Va., contributed to this report.

Source: http://news.yahoo.com/bloomberg-cigarette-plan-gets-praise-criticism-063821912--finance.html

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